Zampilimab (Biosimilar Reference Antibody) (TGM2)
Zampilimab (Biosimilar Reference Antibody) (TGM2)
Zampilimab (Biosimilar Reference Antibody) (TGM2)-RA0727-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Zampilimab (Biosimilar Reference Antibody) (TGM2)-RA0727 in a linear range of 15.63–125 ng/mL.
Zampilimab (Biosimilar Reference Antibody) (TGM2)

Catalog: 

RA0727

Target

TGM2

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Zampilimab (UCB-7858) is an investigational human monoclonal antibody of the IgG4-kappa isotype that targets tissue transglutaminase 2 (TG2 or TGM2). It is being developed for the treatment of celiac disease and other TG2-mediated disorders, aiming to inhibit the enzymatic activity and pathogenic functions of TG2, which plays a central role in the immune response to gluten.

Synonyms

UCB7858, UCB-7858

CAS

2098280-42-1

Isotype

IgG4 - kappa

Host

Chimeric and Humanised

Target

TGM2

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Tempest R, et al. The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment. Cancers (Basel). 2021 Jun 3;13(11):2788.

References 2

Prat-Duran J, et al. Transglutaminase 2 as a novel target in chronic kidney disease - Methods, mechanisms and pharmacological inhibition. Pharmacol Ther. 2021 Jun;222:107787.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34205140/
https://pubmed.ncbi.nlm.nih.gov/33307141/
https://www.oursmab.com/News/The-transglutaminase-TGM2.html

Target Description

Synonyms

transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)

Biology Area

Cancer Biology;Metabolism

Function

Transglutaminase 2 is a multifunctional calcium-dependent enzyme that catalyzes protein cross-linking. In celiac disease, TG2 deamidates gluten peptides, enhancing their affinity for HLA-DQ2/8 molecules and triggering a strong adaptive immune response. Additionally, extracellular TG2 contributes to inflammation and tissue remodeling. By selectively inhibiting TG2, zampilimab aims to block these key steps in the disease pathogenesis, potentially offering a targeted therapy for celiac disease.

Additional Articles 1

The-transglutaminase-TGM2

Additional Articles 2

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