Codrituzumab (Biosimilar Reference Antibody) (GPC3)
Codrituzumab (Biosimilar Reference Antibody) (GPC3)
Codrituzumab (Biosimilar Reference Antibody) (GPC3)-RA0277-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Codrituzumab (Biosimilar Reference Antibody) (GPC3)-RA0277 in a linear range of 3.91-125 ng/mL.
Codrituzumab (Biosimilar Reference Antibody) (GPC3)

Catalog: 

RA0277

Target

GPC3

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Codrituzumab (also known as GC33 or RG-7597) is an investigational humanized monoclonal antibody that was developed as a targeted therapy for hepatocellular carcinoma (HCC), the most common type of primary liver cancer. It was designed to bind specifically to an antigen that is highly expressed on the surface of HCC tumor cells but largely absent from healthy liver tissue. Despite a strong preclinical rationale, the drug’s clinical development in later-stage trials did not demonstrate a significant survival benefit over existing standard of care, and its development appears to have been discontinued.

Synonyms

GC33, RG7686, RO5137382

CAS

1365267-33-9

Isotype

IgG1 - kappa

Host

Humanised

Target

GPC3

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Mika Endo, et al. Abstract 2747: Anti-glypican-3 monoclonal antibody (codrituzumab/GC33/RO5137382) treatment enhances tumor infiltration of PD-L1-positive macrophages, and combination therapy with anti-PD-L1 monoclonal antibody promotes antitumor effects. Cancer Res (2018) 78 (13_Supplement): 2747.

References 2

Chen G, et al. Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab. Oncotarget. 2018 Jan 2;9(12):10436-10444.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://aacrjournals.org/cancerres/article/78/13_Supplement/2747/627053/Abstract-2747-Anti-glypican-3-monoclonal-antibody
https://pubmed.ncbi.nlm.nih.gov/29535817/
https://www.oursmab.com/News/The-hepatocellular-carcinoma-marker-GPC3.html

Target Description

Synonyms

glypican 3

Biology Area

Tumor Antigens;Cancer Biology

Function

Glypican-3 (GPC3), a heparan sulfate proteoglycan that is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage. GPC3 is overexpressed in approximately 70-80% of hepatocellular carcinomas but shows minimal to no expression in normal adult liver tissue, making it a highly specific tumor marker for HCC.

Additional Articles 1

The-hepatocellular-carcinoma-marker-GPC3

Additional Articles 2

Related Products

Porgaviximab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0277

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Enokizumab (Biosimilar Reference Antibody) (IL9)

Catalog: 

RA0277

Target：

IL9

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Bapotulimab (Biosimilar Reference Antibody) (ILDR2)

Catalog: 

RA0277

Target：

ILDR2

Isotype：

IgG2 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Atoltivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0277

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Tocilizumab (Biosimilar Reference Antibody) (IL6R)

Catalog: 

RA0277

Target：

IL6R/CD126

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Cosfroviximab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0277

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Bempikibart (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0277

Target：

IL7R/CD127

Isotype：

IgG1 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Maftivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0277

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus
Lusvertikimab (Biosimilar Reference Antibody) (IL7R)

Catalog: 

RA0277

Target：

IL7R/CD127

Isotype：

IgG4 - kappa

Applications：

ELISA;FC;Functional Assays;IF

Reactivities：

Human
Odesivimab (Biosimilar Reference Antibody) (Zaire Ebolavirus Glycoprotein)

Catalog: 

RA0277

Target：

Zaire Ebolaviru...

Isotype：

IgG1 - kappa

Applications：

Functional Assays

Reactivities：

Virus

Contact Us

Send your request

Talk to us 

Get a quotation, discuss your requirement, receive advises from our antibody experts without obligation.