Cofetuzumab (Biosimilar Reference Antibody) (PTK7)
Cofetuzumab (Biosimilar Reference Antibody) (PTK7)
Cofetuzumab (Biosimilar Reference Antibody) (PTK7)-RA0618-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Cofetuzumab (Biosimilar Reference Antibody) (PTK7)-RA0618 in a linear range of 3.91-125 ng/mL.
Cofetuzumab (Biosimilar Reference Antibody) (PTK7)

Catalog: 

RA0618

Target

PTK7

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Cofetuzumab (also known as PF-06647020) is an investigational antibody-drug conjugate (ADC) developed for the treatment of solid tumors. It is designed to deliver a potent cytotoxic agent specifically to cancer cells that overexpress a particular tumor-associated antigen, thereby aiming to maximize anti-tumor efficacy while limiting systemic toxicity. Clinical trials have evaluated its safety and preliminary efficacy in patients with advanced cancers, including platinum-resistant ovarian cancer and triple-negative breast cancer.

Synonyms

PF-06523435, hu24

CAS

1869928-62-0

Isotype

IgG1 - kappa

Host

Humanised

Target

PTK7

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Cofetuzumab. IMGT.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/result.action
https://www.oursmab.com/News/Inactivated-tyrosine-protein-kinase-PTK7.html

Target Description

Synonyms

protein tyrosine kinase 7 (inactive), "protein tyrosine kinase 7", "PTK7 protein tyrosine kinase 7", CCK4, "colon carcinoma kinase 4"

Biology Area

Cancer Biology;Developmental Signaling

Function

protein tyrosine kinase 7 (PTK7), a catalytically inactive receptor tyrosine kinase that is aberrantly overexpressed on the cell surface of many epithelial cancers (such as ovarian, breast, lung, and colon cancers) but has limited expression in most normal adult tissues. PTK7 is involved in Wnt signaling pathways and contributes to tumor cell proliferation, migration, and survival.

Additional Articles 1

Inactivated-tyrosine-protein-kinase-PTK7

Additional Articles 2

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