Dazukibart (Biosimilar Reference Antibody) (IFNB1)
Dazukibart (Biosimilar Reference Antibody) (IFNB1)
Dazukibart (Biosimilar Reference Antibody) (IFNB1)-RA0310-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Dazukibart (Biosimilar Reference Antibody) (IFNB1)-RA0310 in a linear range of 3.91-125 ng/mL.
Dazukibart (Biosimilar Reference Antibody) (IFNB1)

Catalog: 

RA0310

Target

IFNB1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Dazukibart is a potent, selective, humanised IgG1 neutralising monoclonal antibody directed against interferon-beta (IFNβ). It is being developed as a novel immunomodulatory therapy, likely for the treatment of autoimmune or inflammatory diseases where the type I interferon pathway, particularly IFNβ, is pathologically overactive. By specifically targeting and neutralising IFNβ, it aims to suppress this key inflammatory driver and restore immune balance.

Synonyms

PF-06823859

CAS

2639474-65-8

Isotype

IgG1 - kappa

Host

Humanised

Target

IFNB1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Fiorentino D, et al. Efficacy, safety, and target engagement of dazukibart, an IFN尾 specific monoclonal antibody, in adults with dermatomyositis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial. Lancet. 2025 Jan 11;405(10473):137-146.聽

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/39798982/
https://www.oursmab.com/News/Type-I-interferon-targets-IFNA1-and-IFNB.html

Target Description

Synonyms

interferon beta 1, IFNB

Biology Area

Cytokine and Chemokine;Immunology

Function

Interferon-beta (IFNβ), a cytokine belonging to the type I interferon family. Type I interferons (including IFNα and IFNβ) are critical components of the innate immune response against viral infections, but their sustained overproduction is a hallmark of several autoimmune diseases, most notably systemic lupus erythematosus (SLE) and other interferonopathies. IFNβ binds to a common heterodimeric receptor (IFNAR1/IFNAR2) and activates the JAK-STAT signaling pathway, leading to the transcription of hundreds of interferon-stimulated genes (ISGs). This results in a pro-inflammatory state, immune cell activation, and tissue damage.

Additional Articles 1

Type-I-interferon-targets-IFNA1-and-IFNB

Additional Articles 2

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