Flanvotumab (Biosimilar Reference Antibody) (TYRP1)
Flanvotumab (Biosimilar Reference Antibody) (TYRP1)
Flanvotumab (Biosimilar Reference Antibody) (TYRP1)-RA0806-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Flanvotumab (Biosimilar Reference Antibody) (TYRP1)-RA0806 in a linear range of 0.18–15 ng/mL.
Flanvotumab (Biosimilar Reference Antibody) (TYRP1)

Catalog: 

RA0806

Target

TYRP1

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Flanvotumab (also known as IMC-20D7S) is an investigational, fully human monoclonal antibody developed for the treatment of melanoma. It is designed as a targeted immunotherapy that specifically binds to a differentiation antigen expressed on melanoma cells. The proposed mechanism of action involves the antibody binding to its target on the tumor cell surface, which may then recruit immune effector cells (such as natural killer cells or macrophages) through antibody-dependent cellular cytotoxicity (ADCC) and/or complement-dependent cytotoxicity (CDC) to eliminate the cancer cells. It represents a strategy to direct the immune system specifically against antigen-positive melanoma cells.

Synonyms

20D7S, IMC-20D7S, IMC20D7S

CAS

1188277-05-5

Isotype

IgG1 - kappa

Host

Genetically human

Target

TYRP1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Khalil DN, et al. An Open-Label, Dose-Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma. Clin Cancer Res. 2016 Nov 1;22(21):5204-5210.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/27797971/
https://www.oursmab.com/News/The-target-for-regulating-melanin-production-TYRP1.html

Target Description

Synonyms

tyrosinase-related protein 1, 5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, TRP1, melanoma antigen gp75

Biology Area

Tumor Antigens;Cancer Biology

Function

Tyrosinase-Related Protein 1 (TYRP1), also known as Glycoprotein 75 (gp75). TYRP1 is a type I transmembrane glycoprotein that is an enzyme involved in the melanin biosynthesis pathway. It is a differentiation antigen that is specifically and highly expressed in melanocytes and in the vast majority of malignant melanomas, while its expression in other normal tissues is very limited. This makes it an attractive tumor-associated target for melanoma therapy.

Additional Articles 1

The-target-for-regulating-melanin-production-TYRP1

Additional Articles 2

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