Gatralimab (Biosimilar Reference Antibody) (CD52)
Gatralimab (Biosimilar Reference Antibody) (CD52)
Gatralimab (Biosimilar Reference Antibody) (CD52)-RA0125-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Gatralimab (Biosimilar Reference Antibody) (CD52)-RA0125 in a linear range of 0.18–15 ng/mL.
Gatralimab (Biosimilar Reference Antibody) (CD52)

Catalog: 

RA0125

Target

CD52

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Gatralimab is a next-generation anti-CD52 monoclonal antibody (mAb) that was investigated for the treatment of progressive multiple sclerosis (MS). It belongs to the class of therapies aimed at immune cell depletion to modulate the pathogenic immune response in MS. Gatralimab functions by binding to the CD52 antigen on the surface of a broad range of immune cells, including T cells, B cells, and monocytes. Upon binding, it leads to the depletion of these target cells, primarily through antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).

Synonyms

GZ-402668

CAS

1826020-80-7

Isotype

IgG1 - kappa

Host

Humanised

Target

CD52

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

World Health Organization. WHO Drug Information 2020, vol. 34, 1 [full issue]. WHO Drug Information, 2020, 34(1): 3-141.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://iris.who.int/server/api/core/bitstreams/aee33a1b-8596-4cd3-938c-2ac45c0f944b/content

Target Description

Synonyms

Biology Area

Immunology;CD Markers

Function

CD52, a small, glycosylphosphatidylinositol (GPI)-anchored glycoprotein that is highly expressed on the surface of mature lymphocytes (T cells, B cells), monocytes, macrophages, and eosinophils, but not on stem cells or plasma cells. Its function is not fully understood but may be involved in cell signaling and migration.

Additional Articles 1

Additional Articles 2

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