Riltovetbart (Biosimilar Reference Antibody) (IL31 (Canine))
Riltovetbart (Biosimilar Reference Antibody) (IL31 (Canine))-RA0378-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Riltovetbart (Biosimilar Reference Antibody) (IL31 (Canine))

Catalog: 

RA0378

Target

IL31 (Canine)

Isotype

IgG2 - kappa

Applications

Functional Assays

Reactivities

Canine

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Riltovetbart is a canine-specific IgG2 kappa monoclonal antibody targeting interleukin-31 (IL-31). It neutralizes IL-31, a key pruritogenic cytokine, to reduce itching and inflammation associated with allergic skin diseases in dogs, such as atopic dermatitis.

Synonyms

ZTS-00008183

CAS

2641479-65-2

Isotype

IgG2 - kappa

Host

na

Target

IL31 (Canine)

Reactivity

Canine

Expression System

CHO

Applications

Functional Assays;

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Riltovetbart

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://www.imgt.org/mAb-DB/mAbcard?AbId=1349
https://www.oursmab.com/News/The-inflammatory-itch-cytokine-IL-31.html

Target Description

Synonyms

interleukin 31

Biology Area

Immunology;Cytokine and Chemokine

Function

IL-31, is primarily produced by Th2 cells and directly activates sensory neurons to induce pruritus (itching). By binding to IL-31, riltovetbart blocks its interaction with the IL-31 receptor complex, thereby reducing scratching behavior, skin lesions, and inflammation in canine allergic dermatitis.

Additional Articles 1

The-inflammatory-itch-cytokine-IL-31

Additional Articles 2

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