Sarilumab (Biosimilar Reference Antibody) (IL6R)
Sarilumab (Biosimilar Reference Antibody) (IL6R)
Sarilumab (Biosimilar Reference Antibody) (IL6R)-RA0406-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Sarilumab (Biosimilar Reference Antibody) (IL6R)-RA0406 in a linear range of 15.63–125 ng/mL.
Sarilumab (Biosimilar Reference Antibody) (IL6R)

Catalog: 

RA0406

Target

IL6R/CD126

Isotype

IgG1 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Sarilumab is a fully human monoclonal antibody targeting the interleukin-6 receptor (IL-6R). It binds to both soluble and membrane-bound IL-6R, inhibiting IL-6-mediated signaling. It is approved for the treatment of moderate-to-severe rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, reducing inflammation and joint damage.

Synonyms

REGN88, SAR153191

CAS

1189541-98-7

Isotype

IgG1 - kappa

Host

Genetically human

Target

IL6R/CD126

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

McCarty D, et al. Efficacy and safety of sarilumab in patients with active rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2018;10(3):61-67.

References 2

Xu C, et al. Population Pharmacokinetics of Sarilumab in Patients with Rheumatoid Arthritis. Clin Pharmacokinet. 2019;58(11):1455-1467.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/29492111/
https://pubmed.ncbi.nlm.nih.gov/31055792/
https://www.oursmab.com/News/polygenic-proinflammatory-cytokine-IL6.html

Target Description

Synonyms

interleukin 6 receptor, IL-6R, CD126

Biology Area

Cytokine Receptor;Immunology;CD Markers

Function

IL-6R, is part of the signaling pathway for IL-6, a pro-inflammatory cytokine central to RA pathogenesis. By blocking IL-6R, sarilumab suppresses downstream JAK/STAT signaling, leading to decreased production of acute-phase reactants, reduced synovial inflammation, and alleviation of systemic symptoms. It is often used in patients with inadequate response to conventional disease-modifying antirheumatic drugs (DMARDs).

Additional Articles 1

polygenic-proinflammatory-cytokine-IL6

Additional Articles 2

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