Sirexatamab (Biosimilar Reference Antibody) (DKK1)
Sirexatamab (Biosimilar Reference Antibody) (DKK1)-RA0183-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Sirexatamab (Biosimilar Reference Antibody) (DKK1)

Catalog: 

RA0183

Target

DKK1

Isotype

IgG4 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Sirexatamab is a humanized IgG4 monoclonal antibody targeting Dickkopf-related protein 1 (DKK1), a secreted inhibitor of the Wnt/β-catenin signaling pathway. By binding to and neutralizing DKK1, it restores Wnt pathway activity, promoting bone formation and potentially modulating tumor microenvironment signaling. It is being developed for the treatment of bone metastatic cancers (e.g., prostate, breast cancer) and osteolytic bone diseases.

Synonyms

DKN-01, LY-2812176

CAS

2414962-49-3

Isotype

IgG4 - kappa

Host

Humanised

Target

DKK1

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Klempner SJ, et al. Safety, Efficacy, and Biomarker Results from a Phase Ib Study of the Anti-DKK1 Antibody DKN-01 in Combination with Pembrolizumab in Advanced Esophagogastric Cancers. Mol Cancer Ther. 2021 Nov;20(11):2240-2249.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/34482288/
https://www.oursmab.com/News/DKK1-is-the-core-accomplicker-of-tumor-immune-escape.html

Target Description

Synonyms

dickkopf WNT signaling pathway inhibitor 1, SK, DKK-1

Biology Area

Cancer Biology;Developmental Signaling

Function

DKK1, is overexpressed in many cancers and inhibits Wnt signaling by binding to LRP5/6 co-receptors. Sirexatamab’s blockade of DKK1 enhances osteoblast differentiation and bone mineralization, while also potentially reducing tumor-induced immunosuppression and metastasis in bone niches. This dual action aims to improve skeletal health and anti-tumor responses.

Additional Articles 1

DKK1-is-the-core-accomplicker-of-tumor-immune-escape

Additional Articles 2

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