Tarextumab (Biosimilar Reference Antibody) (NOTCH2 and NOTCH3)
Tarextumab (Biosimilar Reference Antibody) (NOTCH2 and NOTCH3)
Tarextumab (Biosimilar Reference Antibody) (NOTCH2 and NOTCH3)-RA0531-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
ELISA plate pre-coated Antigen protein, can bind Tarextumab (Biosimilar Reference Antibody) (NOTCH2 and NOTCH3)-RA0531 in a linear range of 3.91–125 ng/mL.
Tarextumab (Biosimilar Reference Antibody) (NOTCH2 and NOTCH3)

Catalog: 

RA0531

Target

NOTCH2 and NOTCH3

Isotype

IgG2 - kappa

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Tarextumab is a fully human monoclonal antibody targeting Notch2/3 receptors, key components of the Notch signaling pathway involved in cell differentiation and cancer stem cell maintenance. It binds to both Notch2 and Notch3, inhibiting ligand-induced activation. It was investigated for the treatment of solid tumors, particularly pancreatic cancer and small cell lung cancer, but clinical development was discontinued due to lack of efficacy.

Synonyms

OMP-59R5

CAS

1359940-55-8

Isotype

IgG2 - kappa

Host

Genetically human

Target

NOTCH2 and NOTCH3

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Yen WC, et al. Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency. Clin Cancer Res. 2015 May 1;21(9):2084-95.

References 2

Fu W, et al. EGFR/Notch Antagonists Enhance the Response to Inhibitors of the PI3K-Akt Pathway by Decreasing Tumor-Initiating Cell Frequency. Clin Cancer Res. 2019 May 1;25(9):2835-2847.

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/25934888/
https://pubmed.ncbi.nlm.nih.gov/30670492/
https://www.oursmab.com/News/Nuclear-regulator-of-cell-fate-Notch3.html

Target Description

Synonyms

Biology Area

Cancer Biology;Developmental Signaling

Function

Notch2/3, are transmembrane receptors that, when activated, promote tumor growth, metastasis, and therapy resistance. Tarextumab's blockade aimed to suppress cancer stem cell populations and tumor progression. However, trials failed to demonstrate significant survival benefits, highlighting challenges in targeting Notch signaling in heterogeneous tumors.

Additional Articles 1

Nuclear-regulator-of-cell-fate-Notch3

Additional Articles 2

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