Erenumab (Biosimilar Reference Antibody) (CALCRL)
Erenumab (Biosimilar Reference Antibody) (CALCRL)-RA0062-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.
Erenumab (Biosimilar Reference Antibody) (CALCRL)

Catalog: 

RA0062

Target

CALCRL

Isotype

IgG2 - lambda

Applications

ELISA;FC;Functional Assays;IF

Reactivities

Human

Size (＄)：

100 μg-50;1 mg-210;5 mg-500;10 mg-800;25 mg-1750;50 mg-3000;100 mg-4600

Data Sheet

Material Safety Data Sheet

Certificate of Analysis

Product Description

Erenumab is a fully human monoclonal antibody specifically approved for the preventive treatment of migraine in adults. It belongs to a novel class of migraine-specific therapies known as calcitonin gene-related peptide (CGRP) pathway inhibitors. Erenumab functions as a selective and potent CGRP receptor antagonist. Unlike other CGRP inhibitors that target the ligand (the CGRP peptide itself), erenumab uniquely binds directly to the CGRP receptor, thereby preventing the CGRP peptide from activating the receptor complex. This blockade inhibits the downstream neuroinflammatory and vasodilatory signaling believed to be central to migraine initiation and propagation, leading to a reduction in migraine frequency and severity.

Synonyms

AMG 334, AMG-334, erenumab-aooe

CAS

1582205-90-0

Isotype

IgG2 - lambda

Host

Genetically human

Target

CALCRL

Reactivity

Human

Expression System

CHO

Applications

ELISA, FC, Functional Assays, IF; Recommended dilution: FC, IF:1:200

Purity

>98% by SDS-PAGE

Concentration

Bottled at the concentration indicated on the vial.

Buffer

0.01M PBS, pH 7.4, contains no stabilizers or preservatives.

Endotoxin

<1.0 EU/mg as determined by LAL method

Conjugation

Non-conjugated

Formulation

Liquid or Lyophilized powder Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

store at -20°C or -80°C. Avoid repeated freeze.

Type

Antibody

Purposes

For research use only

References 1

Goadsby PJ, Reuter U, Hallström Y, et al. A Controlled Trial of Erenumab for Episodic Migraine. N Engl J Med. 2017;377(22):2123-2132.

References 2

References 3

References 4

References 5

Product Citations 1

Product Citations 2

https://pubmed.ncbi.nlm.nih.gov/29171821/
https://www.oursmab.com/News/Calcitonin-gene-related-peptide-CGRP.html

Target Description

Synonyms

calcitonin receptor like receptor, calcitonin gene-related peptide receptor, CGRPR, CGRP-R, CRLR

Biology Area

Neuroscience;Pain Biology

Function

Calcitonin gene-related peptide (CGRP) receptor complex. This receptor is composed of two main components: the calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 1 (RAMP1). This complex is expressed on the surface of neurons and smooth muscle cells within the trigeminovascular system. When CGRP binds to this receptor, it triggers a cascade of events that result in cranial vasodilation, neurogenic inflammation, and pain signal transmission—all hallmarks of a migraine attack.

Additional Articles 1

Calcitonin-gene-related-peptide-CGRP

Additional Articles 2

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